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Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8

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Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8

China Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8 supplier
Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8 supplier Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8 supplier

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Product Details:

Place of Origin: MADE IN CHINA
Brand Name: NJBN
Certification: ISO9001 , SGS , KOSHER
Model Number: 34580-14-8

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Checking
Packaging Details: 1kg/25kgs
Delivery Time: 5~8 working days
Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 1000kg per month
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Detailed Product Description
Alias: Ketotifen Fumarate Purity: 99%
Appearance: White Powders Package: 1kg/25kg/piece
Dispatch Time: Within 24h After Payment Stock: Available
Samples: Free
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Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8

 

 

Product Name: Ketotifen fumarate
Synonyms: 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe;hc20-511fumarate;zaditen;4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate;4,9-DIHYDRO-4-(1-METHYL-4-PIPERIDINYLIDENE-10H-BENZO[4,5]CYCLOHEPTA[1,2-B]THIOPHEN-10-ONE) FUMARATE;KETOTIFEN FUMARATE;KETOTIFEN FUMARATE SALT;4,9-dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one fumarate
CAS: 34580-14-8
MF: C23H23NO5S
MW: 425.5
EINECS: 252-100-0
Product Categories: Antagonists;Histaminergics;Neurotransmitters;Histamine receptor;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharmaceutical raw material;SERC;Other APIs;Antiallergic agents
Melting point 192℃
Storage temp. Store at RT
Chemical Properties Off-White Solid
Usage : vasodilator .
Usage Antiasthmatic ; antiallergic.

 

 

Anti-allergic drugs

 

Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. It also has antagonism effect on the calcium ion; can inhibit the activity of phosphodiesterase; increase the intracellular cAMP level inside mast cells.

 

Moreover, it can also inhibiting the chemotaxis and inflammation of neutrophil with an effect 10 times as strong as that of chlorpheniramine, and it also has a long duration time which is better compared with sodium cromolyn. Ketotifen fumarate has therapeutic effect on both Ⅰ and Ⅲ type of allergic reaction. Its peak blood concentrations can sustain for 2 to 3 hours with a half-life of 22 hours during which 60% goes through urinary excretion, 40% goes through the fecal excretion. Children usually have a faster excretion rate of it than adults. Long-term treatment will not cause resistance. No rebound phenomenon will occur with interruption of treatment.

 


Clinical application

 

It has been more than 20 years since ketotifen fumarate have been applied to the prevention and treatment of asthma and childhood asthma. It is a kind of drug with dual effect of both prevention and treatment in the prevention and treatment of asthma and childhood asthma. It should be particularly noted that ketotifen had ever taken as the long-term controlling drug of asthma and childhood long-term asthma and was subject to wide application in many countries. Since the early 1980s, ketotifen fumarate had already been applied in Western Europe, Asia, and China for the prevention and treatment of asthma and asthma in children. But since entering into 21st century, the annual applied amount has decreased year by year. Because of its side effect of inhibition of the central nervous system, its oral tablet currently has still not approved by the FDA and thus failing to enter the US market with only ketotifen fumarate eye drops (ZADITOR) had been approved by the FDA in 1999. Recent studies have also shown the effectiveness of ketotifen asthma still demands further studies. Moreover, ketotifen fumarate has several additional advantages. First, it can cause sleepiness of the schoolchildren and thus being able to affect their academic performance; second, it can also do harm to the mental development of infants and young children. Thirdly, it is also be able to affect the metabolism of sustained-release tea and thus negatively affecting its anti-inflammatory effects of theophylline. For all the above points, it is not recommended by the GINA (affiliated organization of WHO) to apply ketotifen fumarate for the treatment and prevention of asthma and childhood asthma. But from the perspective of clinical economics, ketotifen fumarate is a suitable anti-allergic drug for being applied in developing countries and rural areas for treating asthma and childhood asthma with certain efficacy due to its relative low price .

 


Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas 34580-14-8

 


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FAQ
 
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
 
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
 
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
 
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service
 
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
 
Q6: How should I pay?
A: We accept all kinds of payment ways. such as T/T, Western union, Moneygram , Bitcoin .
 
Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.
 
 

  • For more detailed information , pls feel free to contact me by the following ways :

 
Skype : njbnsteroid
WhatsApp : +8617327093119
E-mail : gearmanager@chembj.com
Website : www.realanabolicsteroids.com

Contact Details
Nanjing Bangnuo Biotechnology Co., Ltd

Contact Person: CPSS

Tel: +8617327093119

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