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Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6

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Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6

China Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6 supplier
Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6 supplier Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6 supplier Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6 supplier Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6 supplier

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Product Details:

Place of Origin: MADE IN CHINA
Brand Name: NJBN
Certification: ISO9001 , SGS , KOSHER
Model Number: 142340-99-6

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Checking
Packaging Details: 1kg/25kgs
Delivery Time: 5~8 working days
Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 1000kg per month
Detailed Product Description
Alias: Adefovir Dipivoxil Purity: 99%
Appearance: White Powders Package: 1kg/25kg/piece
Dispatch Time: Within 24h After Payment Stock: Available
Samples: Free

Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6

 


Product Name: Adefovir Dipivoxil
Synonyms: BIS POM PMEA;BIS(PIVALOYLOXYMETHYL)-9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;9-[2-[bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine;ADEFOVIR DIPIVOXIL;ADEFOVIR PIVOXIL;Adefovir Dipivoxyl;Bis(Pivaloyloxymethyl)-9-[(R)-2-(Phosphonomethoxy)Ethyl]Adenine;AdefovirDipivoxl 98.5%Min
CAS: 142340-99-6
MF: C20H32N5O8P
MW: 501.47
EINECS: 200-001-8
Product Categories: Active Pharmaceutical Ingredients;Adefovir;APIs;Other Products;Bases & Related Reagents;Inhibitors;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Pharmaceutical raw material;API;Bis-POM PMEA, Preveon, Hepsera
Melting point : 98-102°C
Storage temp. : −20°C
Merck : 14,151
Chemical Properties : White Solid
Usage : Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. It is approved for the treatment of chronic hepatitis B in adults with evidence of active vir
Usage : A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI) .

 

 

Regulating human immune system

 

Adefovir dipivoxil regulates the immune system and let the immune system to attack liver cells of the intrusion of HBV , and clear the virus, but this method will develop resistance, at the same time for patients with renal dysfunction or potential renal dysfunction risk, the use of adefovir dipivoxil chronic treatment will lead to renal toxicity. If eating 1 mg every day, in the three months will produce nephrotoxicity, this will lead to severe renal failure. These patients should be closely monitoring renal function and making appropriate dosage adjustments.

 

Bisphosphonates is quick conversion of adefovir dipivoxil in vivo, adefovir dipivoxil is a kind of single adenosine monophosphate acyclic nucleoside analogues, became to activity of the metabolites of adefovir in cellular kinases by phosphorylation in cellular kinases. A Duff Vee two phosphate through the following two ways to suppress HBV DNA polymerase (reverse transcriptase); one is with the natural substrate of deoxyadenosine triphosphate competition, the second is the integration of viral DNA and induce DNA chain elongation terminated. A Duff Vee two phosphate to HBV DNA polymerase inhibition constant (KI) is 0.1μM, but of human DNA polymeraseα and γ is weak and Ki values were 1.18μM and 0.97 μM.

 

Anti-viral activity: in the human hepatoma cell line transfected with HBV, the concentration of A Duff Vee inhibited 50% viral DNA replication (IC50) is from 0.2 to 2.5uM.

 

Adefovir dipivoxil applies for the treatment of hepatitis B virus replication activity and serum amino acid transfer enzyme and persistently elevated liver decompensation adult patients with chronic hepatitis B patients.

 

Liver injury is often encountered in the course of hepatitis B treatment, hepatitis B therapy is inappropriate, as well as long-term use of drugs on the liver damage, will lead to the occurrence of liver damage.

 

After long-term taking adefovir dipivoxil tablets, once the withdrawal will aggravate the damage of liver function. Therefore, for stopping taking the patients should be monitored for liver function.

 

Adefovir dipivoxil is more moderate suitable for long-term use, suitable for patients with lamivudine resistant patients, their chances of producing drug resistance is small, because the amount is less, side effects are small.

 

Entecavir is new, antiviral effect is also strong, if not treated with lamivudine, the possible resistance is the smallest, but it and lamivudine have cross resistance, if treated with lamivudine to take entecavir produced resistance rate is much greater.

 


Adefovir dipivoxil Uses

 

Has a broad spectrum of antiviral activity, can be used for the treatment of chronic hepatitis B .

 


Pure Oral Reverse Transcriptase Inhibitor Adefovir Dipivoxil CAS 142340-99-6
 
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FAQ
 
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
 
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
 
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
 
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service
 
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
 
Q6: How should I pay?
A: We accept all kinds of payment ways. such as T/T, Western union, Moneygram , Bitcoin .
 
Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.
 
 

  • For more detailed information , pls feel free to contact me by the following ways :

 
Skype : njbnsteroid
WhatsApp : +8617327093119
E-mail : gearmanager@chembj.com
Website : www.realanabolicsteroids.com

Contact Details
Nanjing Bangnuo Biotechnology Co., Ltd

Contact Person: CPSS

Tel: +8617327093119

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