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High Purity Pharmaceutical Antihyperlipoproteinemic CAS 163222-33-1 Ezetimibe for High Cholesterol
Product Name: Ezetimibe
Synonyms: 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one;EZETIMIBE;ZETIA;Ezitimibe∬EzetimibeC24H21F2N03;(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone, Sch-58235;1-(4-Flurophenyl)-(3R)-3-(4-flurophenyl)-(3S)-hydroxypropyl-(4S)-(4-hydroxyphenyl)-2-azetidinone;Ezetimide
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Final material;API;Isotope;CEDAX;Cardiovascular APIs;Ezetimibe
Melting point 164-166°C
Storage temp. -20℃ Freezer
Chemical Properties White Solid
Usage An antihyperlipoproteinemic. A Cholesterol absorption inhibitor
Usage A cholesterol transport inhibitor that binds to NPC1L1
Usage For use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia .
What is ezetimibe ?
Ezetimibe reduces the amount of cholesterol absorbed by the body.
Ezetimibe is used to treat high cholesterol.
Ezetimibe is sometimes given with other cholesterol-lowering medications.
Ezetimibe,jointly developed by Schering-Plough and Merck companies ,is the first selective cholesterol absorption inhibitor, the product is first approved by the US FDA listed as selective cholesterol absorption inhibitor class of drugs. Trade name is"EZETROL".
Ezetimibe is a new selective cholesterol absorption inhibitor, it is also the first selective inhibitor of intestinal cholesterol absorption, and its mechanism of action is different from other lipid-lowering agents (such as: statins, bile acid sequestrants, phenoxy acid derivative thereof cattle and plant sterol ester compound), the product ,through binding with the intestinal brush border membrane vesicle membrane protein (relative molecular mass 145X103), inhibits intestinal absorption of cholesterol which is from diet and transported to the intestine via the bile tract , reduces serum and liver cholesterol. Different from acid chelating agent ,ezetimibe does not affect cholesterol esters, other steroids (such as bezoar acid), triglycerides and fat-soluble vitamin absorption. Its pharmacological effects have nothing to do with acetyl coenzyme A- cholesterol acetyltransferase (ACAT) inhibiting and LDL receptors (scavenger receptor) expression . After being absorbed in the liver , ezetimibe combined with glucuronic acid by enterohepatic circulation,is almost specifically targeting to the small intestine mucosa. It can be used alone or in combination with HMG-CoA reductase inhibitors (statins) jointly applied to the treatment of primary (heterozygous familial and non-familial) hypercholesterolemia, homozygous familial hypercholesterolemia (HoFH) homozygous sitosterol hyperlipidemia (hyperlipidemia or phytosterols).
Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin or Inegy) when statins alone do not control cholesterol.
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A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
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A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
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A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
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A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.
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