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White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4

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White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4

China White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4 supplier
White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4 supplier White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4 supplier White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4 supplier White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4 supplier

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Product Details:

Place of Origin: MADE IN CHINA
Brand Name: NJBN
Certification: ISO9001 , SGS , KOSHER
Model Number: 105816-04-4

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Checking
Packaging Details: 1kg/25kgs
Delivery Time: 5~8 working days
Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 1000kg per month
Detailed Product Description
Alias: Nateglinide Purity: 99%
Appearance: White Powders Package: 1kg/25kg/piece
Dispatch Time: Within 24h After Payment Stock: Available
Samples: Free

Pure Quality Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4

 


Product Name: Nateglinide
Synonyms: (-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine;ay4166;Nateglinide(H);trans-d-phenylalanin;trans-n-((4-(1-methylethyl)cyclohexyl)carbonyl)-d-phenylalanine;3-phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoic acid;A-4166;STARLIX
CAS: 105816-04-4
MF: C19H27NO3
MW: 317.42
Product Categories: Active Pharmaceutical Ingredients;API;APIs;Health & Beauty;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;STARLIX;Antidiabetic
Melting point : 137-141°C
Storage temp. : Room temp
Chemical Properties : White Cyrstalline Solid
Usage : antidiabetic KATP channel blocker
Usage : An Amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic .

 

 

Nateglinide Hypoglycemic agents

 

Nateglinide and mitiglinide, repaglinide are three commonly used non-sulfonylurea oral hypoglycemic agents for insulin secretion,it is successfully developed for the first time by the Japanese company Ajomoto , its chemical structure belongs to carbamoylmethyl-benzoic acid (CMBA), it belongs to D- phenylalanine derivatives, it is a new generation of antidiabetic drugs having amino acid structure ,it is an amino acid derivative prompting insulin secretion, it is also currently the only non-sulfonylureas insulinotropic agent having amino acid structure. The mechanism is mainly through binding the pancreatic β cell sulfonylurea receptor, blocking islet cell ATP-sensitive potassium channels, leading to membrane depolarization, causing the calcium channe lopen to promote insulin secretion. This product is a new type of meal blood glucose regulator, which can effectively control the postprandial blood glucose levels, with rapid onset, short duration of action, low incidence of cardiovascular side effects and hypoglycemia and other characteristics .

 

Oral bioavailability is 72%, after 15min it can produce insulin secretion effect, Tmax is 0.5 ~ 0.9 h, 0.2 h insulin levels achieve peak , after 1.5 h it is similar to placebo. The plasma protein binding rate is 99%. After reaching plasmapeak , plasma concentrations decline rapidly.T1 / 2 of oral administration of 120 mg and intravenous injection 60 mg of is 1.5 to 1.7 hours, and the plasma clearance is 7.4 hours. It is metabolized in the liver by isoenzyme CYP2C9 and CYP3A4 way. The main metabolites are products after isomeric oxidation,it can be hydroxyl, diastereomers, isopropyl isomer or unsaturated aliphatic isomers.The main metabolites in plasma and urine are metabolites after the hydroxylation of isopropyl methine family (me-thine carbon) . About 2/3 nateglinide is excreted from the fecal , and the rest is excreted in the urine. Such excretion way is beneficial to elderly Ⅱ diabetes mellitus with renal dysfunction. nateglinide eliminate T1 / 2 is 1.4 h, because nateglinide T1 / 2 is short, there is no report yet about the drug accumulation in the body . Long-term use of nateglinide does not produce drug-induced hypoglycemia caused by drug accumulation .It is used for the treatment of diet therapy, exercise therapy and mild to moderate non-insulin dependent (Ⅱ type) diabetes which taking α- glucosidase inhibitor can not control. The results show that: nateglinide can be used more physiologically for meal glucose control, there is less opportunity for contact with insulin and hypoglycemia which allows patients to flexibly plan scheduling mealtimes, which means there is medication while eating, not eating no medication .

 


Nateglinide Uses

 

It is used for the treatment of diabetes .

 
 
White Powders Antidiabetic Active Pharmaceutical Ingredients Nateglinide 105816-04-4
 
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