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Active Pharma Ingredients Sodium Fusidate CAS 751-94-0 for Antibacterial
|Product name:||Sodium fusidate|
|Leading time||within 24 hours upon receipt of payment|
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|Certification||SGS, ISO 9001, KOSHER|
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|Minimum Order Quantity||10g|
1. Fusidic sodium mycophenolate sodium, also known as brown, fusidic sodium, having a steroid skeleton narrow-spectrum antibiotic, fusidic acid derivatives for the species, the appearance is white crystal or crystalline powder, odorless, bitter, slightly hygroscopic, soluble in water, ethanol, chloroform-soluble and insoluble in the acetone, ether, benzene.
2. It has good antibacterial effect for gram-positive bacteria, it has good resistance. At the same time, this product is still sensitive for penicillin, methicillin antibiotic resistant strains such as, it has no cross resistance for husband sildenafil between sodium and other clinical use of antimicrobial agents.
3. This product is non cephalosporins. There is no need to do skin allergy test. The current clinical treatment has been widely used by a variety of sensitive bacteria, especially Staphylococcus aureus caused by various infections, such as osteomyelitis, septicemia, endocarditis , recurrent infections of cystic fibrosis, myocardial bacterial meningitis, pneumonia, meningitis, diphtheria, tuberculosis, skin and soft tissue infections, surgical wound infections and the like.
4. Intravenous medication is used for severe infection or resistant strains infection, also used for MRSA infection. But due to its easy resistance, much as auxiliary drug use. Oral treatment failure caused by clostridium pseudo membranous enteritis has fine effect.
1.Fusidic sodiumproduce bactericidal effectby inhibiting bacterial protein synthesis,and having strong antibacterial effecton a range for Gram-positive bacteria. Staphylococcus aureus, including penicillin, methicillin and other antibiotics-resistant strains are highly sensitive to the chemicals. It has no cross-resistance between fusidic sodium and other antibacterial drugs in clinical use.
2.Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steriodal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells.
3.Role: steroid skeleton antibiotic mainly has effect against Gram-positive bacteria and Neisseria, Mycobacterium tuberculosis antibacterial. It is used for surrounding infection caused by susceptible strains, especially suitable for resistant to other antibiotics. Commonly used in the skin bone parts, joint infections etc. Packaging: 25 kg per cardboard barrel.
1. Adverse reactions were mild and slight, and there were slight gastrointestinal reactions in the oral administration. Intravenous injection of product can lead to thrombophlebitis and venous spasm. Daily use of 1.5 to 3 grams of reversible would increase aminotransferase according to some reports.
2. There have been reports of individual patients after treatment may appear retrograde jaundice, which is mainly seen in the high-dose intravenous administration, especially in patients with severe S. aureus bacteremia. If persistent jaundice, you should stop using the drug to make the serum bilirubin return to normal. Allergic reactions were rarely reported.
3. Since the metabolism and excretion properties of fusidic sodium, when long-term large doses of medication or in combination with other fusidic sodium discharge pathway similar drugs (such as clindamycin or rifampicin), liver dysfunction and biliary abnormalities patients should regularly check liver function.
4. In in vitro experiments, fusidic sodium may be substituted on the bilirubin albumin binding sites, such substitution clinical significance is unclear. It also did not discover the nuclear jaundices after using this product, but the premature children, jaundice, acidosis and severe sick newborns should pay attention to this factor when using this product.
1. Thiophene is presented in the shale oil and coal tar. First use the waste acid of crude benzene washing as the raw material for hydrolysis at 110-150℃. The gas coming from hydrolysis is put into the overhead condenser through hydrolysis distillation column.
2. The condensed product has content of 15%-25% thiophene, 50%-60% xylene, and also benzene, toluene, methyl thiophene and some unknown substances. Per ton of waste acid can be extracted out for about 10 kg distillation product. After dehydration with solid sodium hydroxide and further refined purification by distillation, you can get thiophene product of 90%-95%.
3. Chemical synthesis of thiophene can use butane and sulfur as raw materials; butane first undergoes dehydrogenation and then form a ring with sulfur to form thiophene. Laboratory prepare thiophene through the reaction between 1,4-dicarbonyl compound and phosphorus trisulfide.
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