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Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan

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Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan

China Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan supplier
Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan supplier Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan supplier Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan supplier Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan supplier

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Product Details:

Place of Origin: MADE IN CHINA
Brand Name: NJBN
Certification: ISO9001 , SGS , KOSHER
Model Number: 119413-54-6

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Checking
Packaging Details: 1kg/25kgs
Delivery Time: 5~8 working days
Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 1000kg per month
Detailed Product Description
Alias: Topotecan Hydrochloride Purity: 99%
Appearance: White Powders Package: 1kg/25kg/piece
Dispatch Time: Within 24h After Payment Stock: Available
Samples: Free

Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6
 
Quick Details for Topotecan hydrochloride
Product Name: Topotecan hydrochloride
Synonyms: TOPOTECAN MONOHYDROCHLORIDE;TOPOTECAN HCL;SKF-104864A;9-[(DIMETHYLAMINO)METHYL]-10-HYDROXY-(20S)-CAMPTOTHECIN, HCL;(4S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4',6-7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE;HYDROCHLORIDE;topetecan hydrochloride;5-PIPERAZIN-1-YL-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
CAS: 119413-54-6
MF: C23H24ClN3O5
MW: 457.91
Product Categories: straight chain compounds;Active Pharmaceutical Ingredients;Antineoplastic;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Chiral Reagents;Inhibitors;Isotope Labelled Compounds;Anti-cancer & immunity;API
Melting point : 213-218°C
Storage temp. : Refrigerator
Chemical Properties : White Crystalline Solid
Usage : Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer)
Usage : antineoplastic; topoisomerase I inhibitor
Usage : A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.
 
Anticancer drug
Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy.
 
In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The Ⅲ clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome.
 
Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors.
 
Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.
 
Topotecan hydrochloride Clinical studies
In a open randomized trial, 226 cases who used cisplatin or carboplatin invalid or recurrent advanced ovarian cancer women changed to this product, and compared with paclitaxel. In 112 patients who used topotecan hydrochloride, 22 cases were effective, so the effective rate was 20%. In 114 patients treated with paclitaxel, 14 cases were effective, so the effective rate was 12%. Used this product for treatment which has made significant improvement in the average time of 23 weeks, while 14 weeks for paclitaxel. In a non-controlled trial to 111 women patients with refractory advanced ovarian cancer, 16 cases were preferabe after treatment, occupied with 14%, and the curative effect average time was 16-week, and the average survival time was 52-week. In an open trial, 67 cases were ineffective treated with cisplatin and paclitaxel for advanced ovarian cancer. However, 9 cases who changed to this product were effective, and the effective rate was 13%.
 
Topotecan hydrochloride Side effects
It can appear toxicity of bone marrow suppression in limited doses, especially it can cause neutropenia. It often induced thrombocytopenia and anemia. Sometimes red blood cell and platelet transfusion is necessary. It can also be nausea, vomiting, hair loss, diarrhea, abdominal pain, gastritis and weakness, but all of them were mild.
 
Topotecan hydrochloride Uses
It is used as antineoplastic agent.
Antineoplastic Pharmaceutical Raw Materials Topotecan Hydrochloride CAS 119413-54-6 Topotecan
 
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