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|Name:||Clobetasol Propionate||Description:||Topical Corticosteroid, Glucocorticoid, Anti-inflammatory|
|Appearance:||White Crystalline Powder||Usage:||Adrenal Cortical Hormone And Adrenal Cortical Hormone|
Highly Effective Glucocorticoid Steroids Clobetasol Propionate 25122-46-7
Clobetasol propionate:Artificial synthesis of highly effective topical corticosteroid drugs, with strong anti-inflammatory, anti itching and capillary contraction effect
Certificate Of Analysis
|Product name||Clobetasol propionate|
|CAS No.||25122-46-7||Outer Packing||1KG/bag|
|Production date||2016.05||Shelf life||2021.04|
|Description||White crystalline powder||White to cream crystalline powder|
|Solubility||Complies||As per USP|
|Identification||Complies||As per USP|
|Melting range||196℃||About 196℃|
|Specific optical Rotation(on dried basis)||+100.92°||+98° to +104°|
|Loss on drying||0.25%||Not more than 2.0%|
|Residue on ignition||0.06%||Not more than 0.1%|
|Heavy Metals||Complies||Not more than 20 ug/gm|
i)Any individual impurity
Not more than1.0%
Not more than2.5%
|Assay(on dried basis)||99.4%||Not less than97.0%&Not more than102.0%|
Not more than 600 ppm
Not more than 5000 ppm
Not more than 5000 ppm
Not more than 3000 ppm
Not more than200 ppm
Not more than 880 ppm
About clobetasol propionate
Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema anddermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Clobetasol propionate relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms.
Specialist skin doctors may on occasion prescribe a short course of clobetasol propionate for the treatment of psoriasis, although it is not generally recommended for this skin condition. Clobetasol propionate is not recommended for use in children, although again, it may be prescribed for a child by a specialist doctor under certain circumstances.
Clobetasol propionate is available as a number of different preparations. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, or an ointment if your skin is dry. It is also available as a shampoo and as an application for the scalp.
There is also a preparation available which contains two antibacterial agents called neomycin and nystatin. You may be prescribed this preparation for short-term use if your skin has become infected. It is typically used twice a day for one week only.
Pharmacology and toxicology
The role of this product is rapidly, is the current clinical application of highly effective topical corticosteroids a strong. Has a strong role in capillary contraction, betamethasone sodium phosphate, 2.3 times, 18.7 times fluocinolone. The systemic side effects were 3 times of the fluoride and the effect of the retention of sodium and potassium, which promoted the excretion of sodium and potassium.
Pharmacokinetics: This product can be absorbed through the skin after topical. Absorption and systemic administration of corticosteroids in vivo metabolism, mainly in the liver metabolism, by the kidneys.
Usage and dosage: external use, a thin layer of evenly applied to the affected area, daily 1 ~ 2 times. In addition to the skin of the palm, plantar and horn of the skin of the skin, the general should not be treated with a packet. 1 weeks dosage can not be more than 50g.
Preparation and specifications: Clobetasol Propionate Ointment: 1.0.05%, 10g:5mg; 2.0.02%, 10g:2mg.
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