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99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE

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99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE

China 99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE supplier
99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE supplier 99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE supplier 99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE supplier 99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE supplier

Large Image :  99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE

Product Details:

Place of Origin: Mainland China
Brand Name: NJBN Local Anesthetic Drugs
Certification: Mainland China , China, Made in China,
Model Number: 51-05-8

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 1kg/Aluminium Foil Bag, 25kg/Drum
Delivery Time: Within 24 hours after receiving the payment
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 3—5 Tons Per Month
Detailed Product Description
Name: Procaine HCl Other Name: Procaine Hydrochloride, Aminocaine, Anadolor, Atoxicocaine
Stock: Adequate Category: Local Anesthetic Powder
CAS: 51-05-8 HS Code: 2932999099

 

99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE

 

  • Quick Detail

 

Product name

Procaine HCl

Other name

Procaine hydrochloride, aminocaine, anadolor, atoxicocaine

Grade

Local Anesthetic Drug, Pharmaceutical, APIS, Anesthetics, Pharmaceutical intermediate

CAS NO.

51-05-8

EINECS

200-077-2

Molecular formula

C13H21ClN2O2

Molecular weight

272.77

Molecular structure

99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE

Appearance

White crystalline powder

High Quality

99.68%

Melting point

155-156 °C

Stock

Adequate

HS Code

2932999099

Export Markets

Global

Production Capacity

3—5 Tons Per Month

Packing

1kg/Aluminium Foil Bag, 25kg/Drum

Storage

Shading, confined preservation

Function

For local anesthesia

Samples Available

Delivery time

Within 24 hours upon receipt of payment

Delivery

EMS, DHL, TNT, FedEx, UPS

Brand NJBN Local Anesthetic Powder
Manufacture Nanjing Bangnuo Biotechnology Co., Ltd
Skype bnsteroid
what's App +8617327094661
Email annahuang@chembj.com

 

  • Procaine Hydrochloride ( Procaine HCL ) and Complexed Procaine

 

Procaine HCL is actually a very simple combination of two B vitamins, PAPA (P-aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. Procaine hydrochloride is a compound combination of PABA and DEAE, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic.

 

  • Why the stabilized procaine HCl was more effective than the unstabilized solutions?

 

  1. The chemistry of procaine showed that procaine in the bloodstream only has a half-life of 0.6 of a minute before destroyed by the enzyme pseudocholinesterase in the bloodstream. The stabilized procaine HCl solution had a half-life of over 6 hours (six hundred times greater active life span in the blood).
  2. The increased life span was due to the fact that the benzoic acid complexed with the procaine HCl forming a double salt of amino groups on the procaine molecule. The HCl hooked to the tertiary amino group on the diethylaminoethanol part of the molecule while at an acid pH of 3-4 the benzoic acid hooked on the p-amino group of the PABA part of the procaine molecule.
  3. This double salt formation caused the procaine molecule to fold over covering the ester linkage, causing steric hindrance, which made the ester linkage of the procaine inaccessible to the splitting action of the pseudocholinesterase enzyme. This extended the useful life of the procaine in the bloodstream giving it more time to be assimilated into the cells.
  4. The amount of benzoic acid used to stabilize the solution by Dr Aslan only complexed 15 mgs of the 100 mgs of procaine HCl in her injectable solution. This left 85 mgs or 85% of the active material to be destroyed in less than 10 minutes by the enzymes in the blood. So naturally one would ask, why not complex the whole 100 mgs of the procaine HCl thus making it 6 times more effective.
  5. However there was a problem the amount of benzoic acid necessary to complex 100 mgs of the Procaine HCl would be more than the law would allow. The law only allows 0.1% of benzoates in any food product. Benzoic acid provides no benefit to the cell. Higher concentrations would be a powerful allergen to many people. The problem was to protect all of the procaine HCl with something other than benzoic acid that could possibly help in the cellular function of the procaine HCl.

 

  • Procaine HCl and its effects on the diseased cells.

 

In summary, the procaine HCl molecules being composed of a molecule of PABA (p-aminobenzoic acid), a B vitamin, hooked through an ester linkage to DEAE (diethylaminoethanol), a precursor to the B vitamin choline, functioned in the body as a true vitamin molecule at a cellular level effecting cell membranes.

Since the diseased state of a cell that is responsible for most degenerative diseases involves or is precipitated by malfunctions of the cell membranes, the inability of the cell to repair and rebuild new healthy membranes, it followed that this compound procaine hydrochloride ( procaine HCl ) could be very useful in helping degenerative diseases by improving the ability of the cell to renew, repair and rebuild diseased cellular membranes thus normalizing cellular function. The normalized healthy cell in turn would correct the functional problems caused by the diseased state.

 

Dr. Ana Aslan continued the research of several French scientists which earlier showed the procaine HCl injections over a period of time would reverse the effects of various forms of arthritis. She stated using injections of procaine HCl on the geriatric patients in her clinic. The results were very promising. However there was a problem the injectable solutions would become cloudy after a short period of time, which made them unusable. She did that which was a common practice at that time (1950's). To stabilize the injectable solution she added benzoic acid, potassium metabisulfite, and disodium phosphate.

These additions stabilized the procaine Hcl solution by maintaining the pH around 3.3. She found that this stabilized procaine HCl was far more effective than the unstabilized procaine HCl solutions. Dr. Aslan's clinical research using Gerovital H3 (GH-3)through the years has contributed greatly to the improved health of tens of thousands of people throughout the world. She died in 1988 at the age of 91. Her contributions to mankind are of great importance. She was truly one of the great scientists of our time.

 

  • Application Of Procaine Hydrochloride ( Procaine HCL ) 

 

  1. Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
  2. Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
  3. Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
  4. Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase,[citation needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.

 

  • Local Anesthetic Powder Families

 

Benzocaine CAS 94-09-7 Lidocaine CAS 137-58-6
Benzocaine hydrochloride CAS 23239-88-5 Dibucaine hydrochloride CAS 61-12-1
Tetracaine hydrochloride CAS 136-47-0 Prilocaine CAS 721-50-6
Procaine CAS 59-46-1 Propitocaine hydrochloride CAS 1786-81-8
Tetracaine CAS 94-24-6 Proparacaine hydrochloride CAS 5875-06-9
Pramoxine Hydrochloride CAS 637-58-1 Lidocaine hydrochloride CAS 73-78-9
Procaine HCl CAS 51-05-8 Articaine hydrochloride CAS 23964-57-0
Lidocaine CAS 137-58-6 Levobupivacaine hydrochloride CAS 27262-48-2
Dibucaine hydrochloride CAS 61-12-1 Ropivacaine hydrochloride CAS 132112-35-7
Prilocaine CAS 721-50-6 Bupivacaine CAS 2180-92-9

 

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Name: AnnaHuang
skype: bnsteroid
what'sApp: +8617327094661
Skype: bnsteroid
Email:  annahuang@chembj.com

 

99.68% Procaine Hydrochloride Local Anesthetic Powder CAS 51-05-8 With PABA DEAE

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