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Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0

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Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0

China Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0 supplier
Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0 supplier Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0 supplier Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0 supplier Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0 supplier

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Product Details:

Place of Origin: Mainland China
Brand Name: NJBNsteroid
Certification: SGS , ISO9001 , KOSHER
Model Number: 136-47-0

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: 1kg/aluminium foil bag, 25kg/drum or as required
Delivery Time: Within one business day after confirming the payment
Payment Terms: Bitcoin, , Western Union, MoneyGram, T/T
Supply Ability: Near 1000-1200kg/per month
Detailed Product Description
Name: Tetracaine HCl Alias: Tetracaine Hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate Hydrochloride; 4-(Butylamino)benzoic Acid 2-(dimethylamino)ethyl Ester Hydrochloride
Brand: NJBNsteroid Tag: Tetracaine Hydrochloride, Tetracaine Hcl, Tetracaine HCL, Local Anesthetic Drug, Local Anesthetic,CAS136-47-0
CAS NO.: 136-47-0 Molecular Formula: C15H25ClN2O2
Molecular Weight: 300.8242 Class: Active Pharmaceutical Ingredients
Melting Point: 149°C

Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0

 

 

Tag: Tetracaine Hydrochloride, Tetracaine Hcl, Tetracaine HCL, Local Anesthetic Drug, Local Anesthetic,CAS136-47-0

 

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Certificate Of Analysis

 

Name Tetracaine Hcl Date of produce 2016/06/03
Batch No. 16060302 Date test 2016/06/04
Quantity 550kg Expiry date 2018/06/02
Inspection basis Standard Of EP8
ITEMS QUALITY STANDARDS RESULTS
Description White or almost white crystalline powder White crystalline powder
Solubility Matching with the working standard Complies

 

Identification

A.By IR, To match with working standard Complies
B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80℃ for 2h,melts at about 131℃

 

Complies

C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops

 

Complies

D. Solution S gives reaction of chlorides.

 

Complies

PH 4.5~6.5 5.64
Residual Solvents Conform to standard Complies
Claruty Solution should be clear Complies
Related Substances Conform to standard Complies
Heavy metals ≤10ppm <10ppm
Loss on drying ≤1.0% 0.36%
Resiue on ignition ≤0.1% 0.05%
Melting range 148℃ 146.7℃~149℃
Assay 99%~101.0% 99.83%

 

Conclusion

 

The Sample Complies With Specification of EP8

 

Biological Activity

 

  1. Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.
  2. Tetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinalanesthesia.
  3. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allostericblocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

Description & Application

 

  • Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

  • Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

 

  • In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

Tetracaine HCL General Information

 

Product name

Tetracaine hydrochloride

Other name

Tetracaine HCl

Class Active Pharmaceutical Ingredients

CAS register number

136-47-0

EINECS

205-248-5

Molecular formula

C15H25ClN2O2

Molecular weight

200-351-1
Molecular structure Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0

Assay

99%
Character

White or off white crystalline powder

Package

1kg/aluminium foil bag, 25kg/drum or as required

Function

Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.

MOQ 1kg
Storage Shading, confined preservation

Shipping

By express courier

Shipping leading time

Within one business day after confirming the payment
Brand NJBNsteroid
Manufacture Nanjing Bangnuo Biotechnology Co., Ltd

 

World market: Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

 

Active Pharmaceutical Ingredients Tetracaine HCl Or Tetracaine Hydrochloride CAS 136-47-0

 

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