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High Potency Active Pharmaceutical Ingredients Isotretinoin CAS 4759-48-2

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High Potency Active Pharmaceutical Ingredients Isotretinoin CAS 4759-48-2

China High Potency Active Pharmaceutical Ingredients Isotretinoin CAS 4759-48-2 supplier
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Product Details:

Place of Origin: MADE IN CHINA
Brand Name: NJBN STEROID
Certification: ISO 9001 , SGS , KOSHER
Model Number: 4759-48-2

Payment & Shipping Terms:

Minimum Order Quantity: 5g
Price: Negotiable
Packaging Details: 5g/ 10g/ 50g/ foil bag or 10kg/ 20kg / drum
Delivery Time: within one business day after receiving the payment
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 300kg per week
Detailed Product Description
Product Name: Isotretinoin CAS: 4759-48-2
Alias: 13-cis-ra , 13-cis-retinoicaci , 13-ra , Accutane , Isoretinoin , Isotrex , Neovitaminaacid , Ro-4-3780. ENIECS: 225-296-0
Molecular Formula: C20H28O2 Purity: 99.5%
Appearance: Yellow Powder Storage: In Stock
MOQ: 5g Payment Terms: Payment Terms
Sample: Free Price: Negotiable
Function: Severe Cystic Acne Treatment Standard: USP32 Standard

High Potency Active Pharmaceutical Ingredients Isotretinoin CAS 4759-48-2

 

  • Quick Details of  Active Pharmaceutical Ingredients Isotretinoin

 

Product name Isotretinoin
Other Name 13-cis-ra , 13-cis-retinoicaci , 13-ra , accutane , Isoretinoin , isotrex , neovitaminaacid , ro-4-3780.
Original China
CAS 4759-48-2
ENIECS 225-296-0
Molecular formula C20H28O2
Brand name NJBNSteroid
Leading time within 24 hours upon receipt of payment
Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity 99.5%
Package Discreet and Hidden package according to specific requirement
Appearance Yellow Powder
Storage −20°C
Certification SGS, ISO 9001, KOSHER
Payment Terms Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity 5g
Price Negotiable
Usage This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment
Molecular structure

High Potency Active Pharmaceutical Ingredients Isotretinoin CAS 4759-48-2

 

 

 

  • Teehnical Test Sheet (TTS) of Active Pharmaceutical Ingredients Isotretinoin

 

TEST ITEMS SPECIFICATION RESULTS
Description Orange Crystal Powder Complies
Identification
The IR absorption spectrum should correspond

Complies
Should exhibits maximum absorption at 354nm Complies
Assay 98.0%-102.0% 99.4%
Loss on drying ≤0.5% 0.07%
Tretinoin ≤1.0% 0.1%
Residue on ignition ≤0.1% 0.02%
Heavy metals <0.002% <0.002%
Conclusion The specification conform with USP32 standard

 

  • Brief Introduction of Active Pharmaceutical Ingredients Isotretinoin

 

Isotretinoin (INN), also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treatsevere nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

 

  • Usage of Active Pharmaceutical Ingredients Isotretinoin

 

Isotretinoin belongs to the first generation of vitamin A acid. It is a stereoisomer of all-trans vitamin A acid. Oral administration has an anti-oil effect which has special effect on severe acne. The mechanism is as follows:

  1. it can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment.
  2. it has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands.
  3. it can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity.
  4. it can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses.
  5. It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so isotretinoin can also suppress tumorigenesis.
  6. when subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role.

 

  • Dosage of Active Pharmaceutical Ingredients Isotretinoin

 

  1. The dose of isotretinoin patients receive is dependent on their weight and the severity of the condition. High-dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 to 1 mg/kg/day, given as a single dose with food). Usually a course will last 8–10 months. A second course may be required. Efficacy appears to be related to the cumulative dose of isotretinoin taken, with a total cumulative dose over each course of 120–150 mg/kg used as a guideline.
  2. Nearly all patients achieve initial clearing of acne during a normal course of isotretinoin therapy. 90% of patients achieve excellent clearance of their acne after a cumulative dose of 150 mg/kg.

 

  • Our promise

 

1.High quality and standard

  • Standard: Enterprise Standard;
  • All Purity≥98%;
  • We are manufacturer and can provide high quality products with factory price.

2. Fast and safe delivery:

  • Parcel can be sent out within 24 hours after payment. Tracking number available;
  • Secure and discreet shipment. Various transportation methods for your choice;
  • Customs pass rate ≥99%;
  • We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3.Service

  • Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
  • Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
  • High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

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Make an order 1.Please let me know the items you are looking for, quantity, and the destination country;
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Packing According to different countries and quantity of orders
Lead Time Arranged within 24 hours upon receipt of your payment
Photos Photos of parcel would be offered to tell apart the steroids in advance
Delivery Time Usually 4-6 working days to reach destinations
Tracking number Offered once it is released on the Net .Normally within 24hours upon the receipt of payment.
After-sale service 24/7 online for problems and concern related to steroids

 

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Contact Person: Jerry Zhang

E-mail: jerryzhang001@chembj.com

Skype: jerryzhang20161

 

 

High Potency Active Pharmaceutical Ingredients Isotretinoin CAS 4759-48-2

 

 

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