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|Alias:||Raloxifene HCL, KEOXIFENE||CAS NO.:||82640-04-8|
|Category:||Anti Estrogen Steroids||Brand:||NJBNSteroid|
|Appearance:||Light Yellow Powder||Purity:||99%|
|Melting Point:||250-253°C||Application:||Used In The Prevention Of Osteoporosis In Postmenopausal Women|
Light Yellow Powder Anti Estrogen Steroids Raloxifene Hydrochloride 82640-04-8
Raloxifene hydrochloride description
|Product name||Raloxifene hydrochloride|
|Other name||Raloxifene HCL;KEOXIFENE;AKOS 92138|
|Possible similar drugs||Evista; Evista|
|CAS register number||82640-04-8|
|Steroid Class||Anti Estrogen Steroids|
|Appearance||Light yellow powder|
|Manufacturer||Nanjing Bangnuo Biotechnology Co., Ltd|
|Treatment for||the treatment/prevention of osteoporosis and reduction of breast cancer riskinpostmenopausalwomen.|
|Storage||Shading, confined preservation|
Use in Cancer
Raloxifene hydrochloride is approved to prevent:
Raloxifene hydrochloride is also approved to prevent and treat:
Raloxifene hydrochloride is also being studied in the treatment of other types of cancer.
Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors. This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism).
Evista is specifically approved for the treatment and prevention of osteoporosis in postmenopausal women, the reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and the reduction in risk of invasive breast cancer in postmenopausal women at high risk of invasive breast cancer. Evista is supplied as a 60 mg tablet designed for oral administration. The recommended initial dose of the drug is one 60 mg tablet daily, which may be administered any time of day without regard to meals.
Mechanism of Action
Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors. This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors. Raloxifene appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density and decreases fracture incidence.
Certificate of Analysis
|Appearance||White &off-white powder||Conforms|
|Grade||Anti Estrogen Steroids||Conforms|
|Soluble in 10% sodium hydroxide solution. Slightly Soluble in methanol. Insoluble in water|
Loss on drying
|Residue on ignition||≤0.1%||0.06%|
|Any unspecified individual impurity 2|
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