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Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor

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Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor

China Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor supplier
Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor supplier Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor supplier Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor supplier Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor supplier

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Product Details:

Place of Origin: Made in china
Brand Name: NJBNS TEROID
Certification: ISO9001
Model Number: 164656-23-9

Payment & Shipping Terms:

Minimum Order Quantity: 5g
Price: Negotiated
Packaging Details: 5g / 10g / 100g / 1000g
Delivery Time: within in hours
Payment Terms: Western Union , MoneyGram , T/T , Bitcoin
Supply Ability: 100kg/month
Detailed Product Description
CAS: 164656-23-9 Product Name: Dutasteride
Purity: 99% Appearance: White Powder.
Alias: Avodart; Duagen MF: C27H30F6N2O2
MW: 528.53 Sample: Free

Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor

 

 

Product Detials:

 

Product Name Dutasteride
Alias Avodart; Duagen
CAS 164656-23-9
MF C27H30F6N2O2
MW 528.53
Purity 99%
Appearance white powder.
                                        Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor
Application Dutasteride is 5α reductase inhibitor

 

General Information:

 

  • Dutasteride capsules have been approved by the FDA for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland . Dutasteride is a dual 5-alpha-reductase inhibitor , blocking both type 1 and type 2 5-alpha-reductase isoenzymes . These enzymes are responsible for converting testosterone into dihydrotestosterone (DHT) in the prostate . In turn, high levels of DTH may accumulate and cause hyperplasia.
  • BPH is a non-cancerous enlargement of the prostate gland , which can lead to the development of lower urinary tract symptoms. According to the National Kidney and Urologic Diseases Information Clearinghouse , more than half of men in their sixties and as many as 90% in their seventies and eighties have some symptoms of BPH . Symptoms of BPH vary, but can include urination problems such as urgency and leaking or dribbling , or more frequent urination , especially at night.

 

Applications:

 

  • Dutasteride (INN , USAN , BAN , JAN) (brand name Avodart), developed by GlaxoSmithKline , is a triple 5α-reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT) . It is used to treat benign prostatic hyperplasia . It increases the risk of erectile dysfunction[3] and decreased sexual desire.

 

COA:

 

Test Items Specification Test Results
Description White or almost white powder Complies
Identification Meet the requirements Complies
Loss on drying ≤0.5% 0.2%
Melting range 246℃~252℃ 246℃~248℃
Heavy metals ≤20ppm Complies
Residue on ignition ≤0.1% Complies
Related substances Biggest Impurities≤0.5% 0.36%
Total Impurity≤1.0% 0.7%
Assay 97.0%~103.0% 99.3%
Conclusion Complies with In-house Standard


Medicines to treat benign prostatic hyperplasia:

 

  1. On October 9 , 2002 , dutasteride that was developed by GSK was approved by the US Food and Drug Administration for the use in the treatment of prostate enlargement.
  2. On June 19 , 2008 , GSK announced that the FDA approved for the combination of idutasteride and tamsulosin in the treatment of prostate hyperplasia.
  3. In China , on of two elderly men over the age of 60 have benign prostatic hyperplasia . It can cause urinary tract symptoms , including significant rise in frequency of urination , thin urine flow , bladder emptying difficulties , as well as nocturia . It even can cause serious complications , like acute urinary retention, reduce the patients’ life quality , and affect their social life.
  4. Dutasteride is the first and the only dual 5α reductase inhibitor to be used in the treatment of prostatic hyperplasia . It can improve urinary system symptom, reduce the onset of acute urinary retention and the risk of prostate surgery . Tamsulosin is α receptor blockers . It can improve the symptom of prostate hyperplasia .
  5. The human body has both type I reductase and type II 5α reductase . Type II mainly exists in the prostate . And type I mainly distributes in the liver and skin. 5α Reductase is the important reason that leads benign hyperplastic prostate disease continuous developing . It can make testosterone in patients’ prostate transform to DHT with stronger activity , which can cause prostate cells hyperplasia and prostate hypertrophy . Therefore , the inhibition of 5α reductase is the key to treat benign prostatic hyperplasia . And dutasteride can inhibit the type I and type II 5α reductase at the same time . Through this double inhibition mechanism , dutasteride can rapidly and continuously decrease prostate volume, significantly improve the urinary symptoms , reduce the risk of acute urinary retention and related prostate surgery , and bring benefit to patients with persistent , especially the middle and severe patients with benign prostatic hyperplasia.

 

Contact information:

 

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Skype lxq1994yc
Email eve@chembj.com
Whatsapp +8617327094392
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Dutasteride Active Pharmaceutical Ingredients CAS 164656-23-9 99% 5α Reductase Inhibitor

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